Fibromatosis: A review of the risk factors for recurrence and outcomes


Fibromatosis ; desmoid ; fibrous ; tumour ; recurrence

Published online: May 29 2020

M. Horsley, M. S. Arshad, T. Khan

From the Wrightington Hospital to Manchester Foundation Trust, Dept. of Trauma & Orthopaedics, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL


Aggressive fibromatosis is a rare condition. These benign fibrous tumours can develop in connective tissue. Wide-margin resection is the favoured method of treatment, however, radiotherapy and chemotherapy can also be used, to reduce the rate of recurrence.

We undertook a retrospective analysis of case notes of patients who had been diagnosed with aggressive fibromatosis. Data regarding treatments received and whether the tumours had recurred was collected. We also evaluated any other factors that may have influenced the risk of recurrence in these patients.

The recurrence rate was 47% overall, with the main risk factors being a younger age (below 30 years), being female and larger size of tumour. Patients were also more likely to have a recurrence if their original tumour was in the lower limb.

We conclude that high recurrence rate, may be reduced in future with patient-specific treatments based on patient characteristics, tumour histology and limb targeted therapies when a wider evidence base is achieved.