Should tranexamic acid be used for 3 days after total knee replacement? A randomized study in 250 patients

Keywords:

Tranexamic acid; total knee replacement; routes; duration


Published online: Feb 16 2022

https://doi.org/10.52628/87.4.14

Nilen Shah, Vatsal Khetan, Hari Sivanadan

From the Smt S R Mehta and Sir K P Cardiac Institute, Mumbai, India

Abstract

The aim is to study whether a 3 day course of Tranexamic acid (TXA) is more effective in reducing blood loss following a TKR than a 1 day course. 250 patients were prospectively randomised into Group A (n=138; Perioperative and additional oral TXA for two days) and Group B (n=112; only perioperative TXA). Total Blood loss was calculated by the Haemoglobin (Hb) loss method at 4 days and compared in both groups using Mann Whitney test. The mean peri- operative blood loss in group A was 631.69 ± 264.99 ml as compared to 685.55 ± 239.033 ml in group B (p=0.0434). Use of TXA for 3 days following a TKR can be more effective in reducing blood loss.  

ActaOrthopBelg-87-3-cover

About this issue

Volume 87, issue 4.

Dec 2021.

Open access journal

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